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Semaglutide Informational

Trident Primary Care & Wellness Center

Your Health & Wellness is our Mission

What You Need to Know

Semaglutide (also known by Ozempic and Wegovy) is a medication that belongs to a class of drugs known as GLP-1 receptor agonists. Semaglutide is also FDA approved for weight loss and is administered once a week by injection.

Semaglutide mimics the natural occurring hormones that the body makes which tells the brain I'm full. It promotes weight loss in people by reducing appetite, slowing down the emptying of the stomach, and increasing feelings of fullness.

Semaglutide has been found to reduce the risk of cardiovascular disease, including reducing the risk of heart attacks, strokes, and other cardiovascular events. Semaglutide can also reduce the risk of kidney disease in people with type 2 diabetes.

Starting dose (0.25mg) injection every week times 4 weeks (can be increased after 4 weeks) 0.50mg, 1mg, 1.5mg lastly 2.5mg. Goal is to reach (2.4mg) injection every week by month 5.

Semaglutide + reduced calorie meal plan + increased physical activity = Weight Loss

While the medication starts to work immediately, it may be a few weeks before results are seen. Injections should be taken on the same day each week. Rotate injection sites to minimize skin irritation. Sites for injections include fatty areas like abdomen, thighs, and upper arms.

Common side effects: gas, nausea, vomiting, Constipation, diarrhea, abdominal pain, bloated feeling, and belching. These side effects usually occur when the patient first gets their injection or when they are being titrated upward. The side effects generally decrease over time.

To help decrease the GI side effects, patients should: avoid high carbohydrate foods, greasy foods and sugary foods and drinks, cut down on food portion sizes, eat more slowly, chew more thoroughly, and avoid laying down immediately after eating.

Hydration is of the utmost importance: Because Semaglutide decreases appetite, some patients may forget to eat or drink. This can lead to some element of dehydration, which can lead to or exacerbate nausea, constipation, fatigue, malaise, dizziness, or even more dangerous issues such as acute kidney injury. To best avoid this, it is suggested to drink at least 64 ounces of water each day or more based on the patient's activity level.

Who should avoid Semaglutide?

Patients with history of Medullary thyroid cancer or strong family history of Medullary thyroid
cancer.
Patients with a history of kidney disease. Semaglutide could worsen the kidneys causing kidney
failure.
Patients with a history of pancreatic disease. Although rare, Semaglutide can cause pancreatitis.
Patients with diabetic retinopathy. Semaglutide can worsen this condition.
Patients with depression or suicide ideation. Semaglutide can worsen these conditions.
Patients that are pregnant or planning on being pregnant in the next two months.

Tips for Patients

Keep a journal to track your progress. Record meals, noting what you ate and how it made you feel. Record water intake.
Record where you received your injection and how you feel after each shot. Which site works better and/or causes the least side effects?
Record positive changes in weight, food changes, and mental changes.
Record physical activities and which, if any, lead to better weight loss.
Keep high protein bars or shakes handy.
Drink plenty of water.